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PCDH12 Antibody

Catalog # Availability Size / Price Inquiry
APR12752G 0.1 mg / $695

PCDH12 Antibody

Brand

Leading Biology

Catalog Number

APR12752G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PCDH12 antibody.

Molecular Weight

128995 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

PCDH12; This antibody is predicted to not cross-react with PCDH18.

Isotype

IgG

GeneID

UniProt ID

Function

Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).

Summary

PCDH12 Antibody: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Images

Western blot analysis of PCDH12 in K562 cell lysate with PCDH12 antibody at 2 μg/mL.

Immunohistochemistry of PCDH12 in rat lung tissue with PCDH12 antibody at 5 μg/mL.

Specification

Quantity

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