We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality A2B Adenosine Receptor (extracellular) antibody.

36333 Da

Rabbit

Human, Mouse, Rat

Peptide KDSATNN*STEPWDGTTNESC, corresponding to amino acid residues 147-166 of human?A2B Adenosine Receptor?with replacement of cysteine 154 (C154) with serine (*S) (Accession P29275). 2nd extracellular loop.

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors):A1-Adenosine Receptor (A1AR), A2A-Adenosine Receptor (A2AAR), A2B-Adenosine Receptor (A2BAR), and A3-Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important in binding G proteins.1-3 The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4 The A2 Adenosine receptor subtype was subdivided according to affinity for adenosine; A2AAR has high affinity and A2BAR has low affinity. A2BAR is expressed in mast cells, neutrophils, monocytes, macrophages, dendritic cells, T cells, bronchial epithelium, intestinal epithelium, smooth muscle, brain, and other cells.5 In intestinal epithelia, A2BAR was found to be the major adenosine receptor subtype expressed and is thought to be involved in diarrheal diseases. It is also believed to be involved in the pathogenesis of chronic airway inflammatory diseases.4 Thus, antagonists of A2BAR might be effective for the treatment of inflammatory gastrointestinal tract disorders4 as well as asthma and chronic obstructive pulmonary disease.5 Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the human A2B Adenosine receptor (A2BAR). The Anti-A2B-Adenosine Receptor (extracellular) antibody (#AG1385) can be used for western blot immunohistochemical applications. It has been designed to recognize A2B-Adenosine receptor from human, rat and mouse samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB, IHC, FC

WB~~1:200-1:2000 IHC~~1:50

Adenosine receptor A2b, ADORA2B

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