> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > WIPI1 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR10749G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality WIPI1 antibody (Center).
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Molecular Weight |
48673 Da
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Cellular Localization |
Antigen Cellular Localization:
Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle Preautophagosomal structure membrane; Peripheral membrane protein Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
202-232 aa
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Target |
This WIPI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-232 amino acids from the Central region of human WIPI1.
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Isotype |
Rabbit Ig
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Symbol |
WIPI49
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GeneID |
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UniProt ID |
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Function |
Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
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Summary |
WD40 repeat proteins are key components of many essentialbiologic functions. They regulate the assembly of multiproteincomplexes by presenting a beta-propeller platform for simultaneousand reversible protein-protein interactions. Members of the WIPIsubfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladedpropeller structure and contain a conserved motif for interactionwith phospholipids (Proikas-Cezanne et al., 2004 [PubMed15602573]).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
WD repeat domain phosphoinositide-interacting protein 1, WIPI-1, Atg18 protein homolog, WD40 repeat protein interacting with phosphoinositides of 49 kDa, WIPI 49 kDa, WIPI1, WIPI49
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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