> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TGM3 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR10429G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TGM3 antibody (C-term).
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Molecular Weight |
76632 Da
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
539-567 aa
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Target |
This TGM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-567 amino acids from the C-terminal region of human TGM3.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath.
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Summary |
Transglutaminases are enzymes that catalyze thecrosslinking of proteins by epsilon-gamma glutamyl lysineisopeptide bonds. While the primary structure of transglutaminasesis not conserved, they all have the same amino acid sequence attheir active sites and their activity is calcium-dependent. Theprotein encoded by this gene consists of two polypeptide chainsactivated from a single precursor protein by proteolysis. Theencoded protein is involved the later stages of cell envelopeformation in the epidermis and hair follicle.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Protein-glutamine gamma-glutamyltransferase E, Transglutaminase E, TG(E), TGE, TGase E, Transglutaminase-3, TGase-3, Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain, Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, TGM3
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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