> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > FDPS Antibody (N-term)Brand |
Leading Biology | Catalog Number |
AMM04520G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FDPS antibody (N-term).
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Molecular Weight |
48275 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
54-82 aa
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Target |
This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.
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Isotype |
Rabbit Ig
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Symbol |
FPS, KIAA1293
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GeneID |
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UniProt ID |
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Function |
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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Summary |
This gene encodes an enzyme that catalyzes the productionof geranyl pyrophosphate and farnesyl pyrophosphate fromisopentenyl pyrophosphate and dimethylallyl pyrophosphate. Theresulting product, farnesyl pyrophosphate, is a key intermediate incholesterol and sterol biosynthesis, a substrate for proteinfarnesylation and geranylgeranylation, and a ligand or agonist forcertain hormone receptors and growth receptors. Drugs that inhibitthis enzyme prevent the post-translational modifications of smallGTPases and have been used to treat diseases related to boneresorption. Multiple pseudogenes have been found on chromosomes 1,7, 14, 15, 21 and X. Multiple transcript variants encodingdifferent isoforms have been found for this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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