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COX7A2L Antibody (Center)

Catalog # Availability Size / Price Inquiry
APG02736G 100 μl / $495

COX7A2L Antibody (Center)

Brand

Leading Biology

Catalog Number

APG02736G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality COX7A2L antibody (Center).

Molecular Weight

12615 Da

Cellular Localization

Antigen Cellular Localization: Mitochondrion inner membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

37-65 aa

Target

This COX7A2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the Central region of human COX7A2L.

Isotype

Rabbit Ig

Symbol

COX7AR, COX7RP

GeneID

UniProt ID

Function

Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).

Summary

Cytochrome c oxidase (COX), the terminal component of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. This component is aheteromeric complex consisting of 3 catalytic subunits encoded bymitochondrial genes and multiple structural subunits encoded bynuclear genes. The mitochondrially-encoded subunits function inelectron transfer, and the nuclear-encoded subunits may function inthe regulation and assembly of the complex. This nuclear geneencodes a protein similar to polypeptides 1 and 2 of subunit VIIain the C-terminal region, and also highly similar to the mouseSig81 protein sequence. This gene is expressed in all tissues, andupregulated in a breast cancer cell line after estrogen treatment.It is possible that this gene represents a regulatory subunit ofCOX and mediates the higher level of energy production in targetcells by estrogen.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:10~50

Synonyms

Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, EB1, COX7A2L, COX7AR, COX7RP

Images

Anti-COX7A2L Antibody (Center) at 1:1000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 13 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

COX7A2L Antibody (Center) (Cat. APG02736G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).

COX7A2L Antibody (Center) (Cat. APG02736G) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).

Specification

Quantity

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