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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > PGP9.5 / UchL1 (pan-Neuronal Marker) Antibody - With BSA and Azide

PGP9.5 / UchL1 (pan-Neuronal Marker) Antibody - With BSA and Azide

Catalog # Availability Size / Price Inquiry
AMM05507G 50 μg / $395

PGP9.5 / UchL1 (pan-Neuronal Marker) Antibody - With BSA and Azide

Brand

Leading Biology

Catalog Number

AMM05507G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PGP9.5 / UchL1 (pan-Neuronal Marker) antibody - With BSA and Azide.

Molecular Weight

20-30kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Target

Native UchL1 (PGP9.5) protein from brain

Clone

13C4

Isotype

IgG2a, kappa

GeneID

UniProt ID

Function

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Summary

This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.

Form

0.5 ml at 200ug/ml with BSA and azide

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC, IF, E

Synonyms

Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, 6---, Neuron cytoplasmic protein 95, PGP 95, PGP95, Ubiquitin thioesterase L1, UCHL1

Images

Specification

Quantity

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