> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Synaptojanin-2 AntibodyBrand |
Leading Biology | Catalog Number |
AMM08055G |
Product Type |
Monoclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Synaptojanin-2 antibody.
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Molecular Weight |
165538 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane. Note=Predominantly associated with the particulate fractions.
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
A synthetic peptide corresponding to residues near the N-terminus of human Synaptojanin 2 is used as an immunogen.
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Clone |
EPR2062Y
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Symbol |
KIAA0348
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GeneID |
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UniProt ID |
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Function |
Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
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Summary |
Synaptojanin is an inositol 5?0phosphatase and take part in membrane trafficking processes and signal transduction (1). Two isoform of Synaptojanin exists, Synaptojanin 1 (aka Synaptojanin) and Synaptojanin 2. Synaptojanin is mainly expressed in nerve terminals and is involved in clathrin-mediated synaptic vesicle recycling in neuronal cells (2). Ubiquitously expressed and with high catalytic domains homology to Synaptojanin, Synaptojanin 2 is considered as a Rac1 effector. Synaptojanin 2 possibly medicates the inhibitory effect of Rac1 on clathrin-mediated endocytosis. Synaptojanin 2 contributes to Rac1?s role in cell invasions and migration by regulation the formation of specialized membrane structures in ECM (invaodopoida and lamellipoida). Synaptojanin 2 is considered to be a novel target for therapeutic intervention in malignant tumors.
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Form |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:500000
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Synonyms |
Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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