> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PYHIN1 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR05643G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PYHIN1 Antibody (N-term).
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Molecular Weight |
55065 Da
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Cellular Localization |
Antigen Cellular Localization:
Isoform 1: Nucleus, nucleoplasm. Isoform 5: Nucleus. Nucleus speckle.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
26-55 aa
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Target |
This PYHIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PYHIN1.
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Isotype |
Rabbit Ig
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Symbol |
IFIX
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GeneID |
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UniProt ID |
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Function |
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
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Summary |
PYHIN1 belongs to the HIN200 family ofinterferon-inducible proteins that share a 200-amino acid signaturemotif at their C-terminal ends. HIN200 proteins are primarilynuclear and are involved in transcriptional regulation of genesimportant for cell cycle control, differentiation, and apoptosis(Ding et al., 2006 [PubMed 16479015]).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, FC, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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