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UBAC1 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
APR05641G 100 μl / $495

UBAC1 Antibody (C-term)

Brand

Leading Biology

Catalog Number

APR05641G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality UBAC1 Antibody (C-term).

Molecular Weight

45338 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm

Host

Rabbit

Species Reactivity

Human

Immunogen

264-292 aa

Target

This UBAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-292 amino acids from the C-terminal region of human UBAC1.

Isotype

Rabbit Ig

Symbol

GBDR1, KPC2, UBADC1

GeneID

UniProt ID

Function

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Summary

UBAC1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein has two RRM domains that bind to RNAs.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, FC, E

Dilution

WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50

Images

UBAC1 Antibody (C-term) (Cat. APR05641G) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the UBAC1 antibody detected the UBAC1 protein (arrow).

UBAC1 Antibody (C-term) (Cat. APR05641G) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the UBAC1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

UBAC1 Antibody (C-term) (Cat. APR05641G) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specification

Quantity

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