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SF3B1 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR22380N-1 50ul / $395
APR22380N-2 100ul / $495
APR22380N-3 200ul / $595

SF3B1 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR22380N

Product Type

Polyclonal Antibodies

Field of Research

Epigenetics & Nuclear Signaling>RNA Binding

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SF3B1 Polyclonal Antibody.

Molecular Weight

Calculated MW: 16kDa/145kDa Observed MW: 160kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human SF3B1 (NP_001005526.1).

Cross Reactivity

Human,Mouse

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

SF3B1; Hsh155; MDS; PRP10; PRPF10; SAP155; SF3b155; splicing factor 3B subunit 1

Images

Western blot analysis of extracts of various cell lines, using SF3B1 antibody.

Specification

Quantity

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