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ITCH Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR22182N-1 50ul / $395
APR22182N-2 100ul / $495
APR22182N-3 200ul / $595

ITCH Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR22182N

Product Type

Polyclonal Antibodies

Field of Research

Cell Biology & Developmental Biology>Apoptosis

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ITCH Polyclonal Antibody.

Molecular Weight

Calculated MW: 103kDa Observed MW: 103kDa

Species Reactivity

Rabbit

Immunogen

A synthetic peptide of human ITCH (NP_001244066.1).

Cross Reactivity

Human

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms

ITCH; ADMFD; AIF4; AIP4; NAPP1; itchy E3 ubiquitin protein ligase

Images

Western blot analysis of extracts of 293T cells, using ITCH antibody.

Specification

Quantity

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