> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > LDLR Polyclonal AntibodyBrand |
Leading Biology | Catalog Number |
APR21548N |
Product Type |
Polyclonal Antibodies | Field of Research |
Cardiovascular>Cardiovascular diseases |
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LDLR Polyclonal Antibody.
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Molecular Weight |
Calculated MW:
75kDa/76kDa/82kDa/90kDa/95kDa
Observed MW:
120kDa
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Species Reactivity |
Rabbit
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Immunogen |
A synthetic synthetic peptide of human LDLR (NP_000518.1).
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Cross Reactivity |
Human,Mouse
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Purity |
Affinity purification |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Storage Buffer |
Buffer: PBS with 50% glycerol, pH7.3.
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Applications |
WB
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Dilution |
WB 1:500 - 1:2000
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Product Description |
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
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Synonyms |
LDLR; FH; FHC; LDLCQ2; low-density lipoprotein receptor
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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