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FZD6 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR18129N-1 50ul / $395
APR18129N-2 100ul / $495
APR18129N-3 200ul / $595

FZD6 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR18129N

Product Type

Polyclonal Antibodies

Field of Research

Cell Biology & Developmental Biology>ESC Pluripotency and Differentiation

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FZD6 Polyclonal Antibody.

Molecular Weight

Calculated MW: 75kDa/79kDa Observed MW: 79kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human FZD6 (NP_003497.2).

Cross Reactivity

Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IHC

Dilution

WB 1:1000 - 1:2000 IHC 1:50 - 1:200

Product Description

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Synonyms

FZD6; FZ-6; FZ6; HFZ6; NDNC10; frizzled-6

Images

Western blot analysis of extracts of various cell line, using FZD6 antibody.

Specification

Quantity

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