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TYMS Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR18064N-1 50ul / $395
APR18064N-2 100ul / $495
APR18064N-3 200ul / $595

TYMS Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR18064N

Product Type

Polyclonal Antibodies

Field of Research

Endocrine & Metabolism>Nucleotide metabolism

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TYMS Polyclonal Antibody.

Molecular Weight

Calculated MW: 26kDa/31kDa/35kDa Observed MW: 36kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human TYMS (NP_001062.1).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB,IF

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Product Description

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Synonyms

TYMS; HST422; TMS; TS; thymidylate synthase

Images

Western blot analysis of extracts of various cell lines, using TYMS antibody.

Immunofluorescence analysis of C6 cells using TYMS antibody.

Immunofluorescence analysis of NIH/3T3 cells using TYMS antibody.

Specification

Quantity

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