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C2 Polyclonal Antibody

Catalog # Availability Size / Price Inquiry
APR17805N-1 50ul / $395
APR17805N-2 100ul / $495
APR17805N-3 200ul / $595

C2 Polyclonal Antibody

Brand

Leading Biology

Catalog Number

APR17805N

Product Type

Polyclonal Antibodies

Field of Research

Immunology & Inflammation>Cell Intrinsic Innate Immunity Signaling Pathway

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality C2 Polyclonal Antibody.

Molecular Weight

Calculated MW: 60kDa/69kDa/83kDa Observed MW: 70kDa/110kDa

Species Reactivity

Rabbit

Immunogen

Recombinant fusion protein of human C2 (NP_000054.2).

Cross Reactivity

Human,Mouse,Rat

Isotype

IgG

GeneID

UniProt ID

Purity

Affinity purification

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Storage Buffer

Buffer: PBS with 50% glycerol, pH7.3.

Applications

WB

Dilution

WB 1:500 - 1:2000

Product Description

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Synonyms

C2; ARMD14; CO2; complement C2

Images

Western blot analysis of extracts of various cell lines, using C2 Antibody.

Specification

Quantity

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