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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Galanin Receptor Type 2 Antibody

Galanin Receptor Type 2 Antibody

Catalog # Availability Size / Price Inquiry
APG03317G 50 μl / $695

Galanin Receptor Type 2 Antibody

Brand

Leading Biology

Catalog Number

APG03317G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Galanin Receptor Type 2 antibody.

Molecular Weight

40516 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Peptide(C)GSGSQRAKRKVTR, corresponding to amino acid residues 223-235 of mouse Galanin receptor type 2 (Accession O88854). 3rd intracellular loop.

GeneID

UniProt ID

Summary

Galanin is a neuropeptide, consisting of 29-30 amino acid residues, involved in the regulation of cognition, mood, feeding, seizure activity and pain. Galanin exerts its action via three known Galanin Receptors, the Galanin Receptor Type 1 (GALR1), Galanin Receptor Type 2 (GALR2) and Galanin Receptor Type 3 (GALR3). The Galanin Receptors belong to the G-Protein Coupled Receptor superfamily.1-4 GALR2 is widely expressed in the brain (with highest levels of mRNA found in the hypothalamus, hippocampus, amygdala and pyriform cortex) and in peripheral tissues such as the small intestine, heart, kidney, and liver. GALR2 high levels of expression were also found in rat dorsal root ganglia.1 GALR2 activation increases inositol phosphate hydrolysis, mediates the release of Ca2+ into the cytoplasm from intracellular stores, and opens Ca2+-dependent chloride channels in a PTX-resistant manner, indicating that GALR2 couples to Gq/11 proteins.5 Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of mouse Galanin Receptor type 2 (GALR2). Anti-Galanin Receptor Type 2 antibody (#AG1240) can be used for Western blot analysis and immunohis

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC

Dilution

WB~~1:200-1:2000 IHC~~1:100

Synonyms

Galanin receptor type 2, GAL2-R, GALR-2, Galr2, Galnr2

Images

Western blot analysis of rat hippocampus, DRG (lanes 2 and 5), brain (lanes 3 and 6), mouse brain (lanes 7 and 9) and human prostate carcinoma LNCaP cell lysates: 1, 2, 3, 7, 8. Anti-Galanin Receptor Type 2 antibody ( APG03317G), (1:200). 4, 5, 6, 9, 10. Anti-Galanin Receptor Type 2 antibody, preincubated with the control peptide antigen

Expression of GALR2 in rat DRG Immunohistochemical staining of rat dorsal root ganglia (DRG) frozen sections using Anti-Galanin Receptor Type 2 antibody ( APG03317G), (1:100). GALR2 is expressed in the DRG neurons. Hoechst 33342 is used as the counterstain.

Specification

Quantity

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