>
Antigen, Antibodies, ELISA, Western Blot >
Primary Antibody >
Polyclonal Antibodies >
Melanocortin Receptor 2 (extracellular) AntibodyBrand |
Leading Biology | Catalog Number |
APR08419G |
Product Type |
Polyclonal Antibodies | Field of Research |
|
Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Melanocortin Receptor 2 (extracellular) antibody.
|
||
Molecular Weight |
33927 Da
|
||
Host |
Rabbit
|
||
Species Reactivity |
Rat
|
||
Target |
Peptide (C)RNMGYLKPRGSFE,?corresponding to amino acid residues 87-99 of human MC2R (Accession Q01718). 1st extracellular loop.
|
||
GeneID |
|||
UniProt ID |
|||
Summary |
Melanocortin Receptor 2 (MC2R) belongs to a five-member receptor family known as the melanocortin receptors. The melanocortin receptors are members of the 7 transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The receptors ligands, the melanocortins, are a group of structurally derived peptides consisting of α-, ?- and γ melanocyte stimulating hormone (α, ?, γ-MSH) and the adrenocorticotropic hormone (ACTH) all of which are derived from the post-translational processing of a common precursor peptide, proopiomelanocortin (POMC).1,2,3 One of the most salient features of the melanocortin signaling system is the presence of two endogenous antagonists, that is proteins that bind specifically to the receptor but instead of activating it have an inhibitory effect. The antagonist proteins are termed agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP).4 All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti and AGRP) with different affinities. MC2R can be also described as the ACTH receptor as it is exclusively activated by the ACTH hormone. In fact, MC2R mediates all the physiological effects of ACTH in the adrenal cortex, that is the regulation and production of steroids, their circadian variation and their stress-related fluctuations.1, 2, 3 In addition, mutations that result in MC2R functional impairment are associated with familial glucocorticoid deficiency.4 The receptor transduces signals via Gs resulting in the activation of adenylate cyclase and production of cAMP. Abgent is pleased to offer a highly specific antibody directed against the extracellular 1st loop of the human MC2R. Anti-Melanocortin Receptor 2 (extracellular) antibody (#AG1213) can be used in Western blot and immunohistochemistry applications, and will recognize human, mouse and rat samples.
|
||
Form |
Affinity purified antibody, Liquid |
||
Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
Applications |
WB, IHC
|
||
Dilution |
WB~~1:200-1:2000
IHC~~1:100
|
||
Synonyms |
Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, MC2R, ACTHR
|
||
Images |
Western blot analysis of rat adrenal lysate: 1. Anti-Melanocortin Receptor 2 (extracellular) antibody ( APR08419G), (1:400). 2. Anti-Melanocortin Receptor 2 (extracellular) antibody, preincubated with the control peptide antigen. Expression of MC2R in rat adrenal gland Immunohistochemical staining of paraffin embedded rat adrenal cortex section using Anti-Melanocortin Receptor 2 (extracellular) antibody ( APR08419G), (1:100). Shown are the capsule (C), the zona glomerulosa (ZG) and the zona fasciculata (ZF) of the adrenal cortex. Note that the staining brown) is specific for cells of the adrenal gland while no staining is present in the dense connective tissue of the capsule. Color reaction was obtained with DAB. H&E is used as the counterstain. |
||
Specification |
|||
Quantity |
|
Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
1 | Leading Biology | APR03440G | ITGA11 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask | ||
2 | Leading Biology | APR04537G | CMIP Antibody (C-term) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask | ||
3 | Leading Biology | APR13816G | TRPM5 Antibody | 50 μl | Polyclonal Antibodies |
|
$695.00 | Add Ask | ||
4 | Leading Biology | APR04506G | PCOLCE2 Antibody (Center) | 100 μl | Polyclonal Antibodies |
|
$495.00 | Add Ask | ||
5 | Leading Biology | APR12422G | Human H4 Histamine Receptor (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
$695.00 | Add Ask | ||
6 | Leading Biology | APR26894N | ASPH Polyclonal Antibody | 100ul | Polyclonal Antibodies | Neuroscience>Calcium Signaling |
|
$495.00 | Add Ask |
Complete this form and click send to ask us a question, request a quote or simply say hello.
You have 0 item in your cart
You have 0 item in your inquiry list