> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > NT4 AntibodyBrand |
Leading Biology | Catalog Number |
AMM06839G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NT4 antibody.
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Molecular Weight |
22427 Da
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Target |
Peptide LGEVPAAGGSPL(C), corresponding to amino acid residues 43-52 of mature human NT-4??(123-132 of the precursor NT-4)??(Accession P34130).
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GeneID |
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UniProt ID |
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Summary |
The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble,basic growth factors which regulate neuronal development, maintenance, survival and death inthe CNS and the PNS.1 Neurotrophin-4 (NT-4) is expressed in neurons of the superior cervical,stellate and celiac ganglion,2 T-cells3 and is synthesized by keratinocytes.4The structural hallmark of all the neurotrophins is the characteristic arrangement of thedisulfide bridges known as the cysteine knot, which has been found in other growth factorssuch as PDGF.5 The rat and human forms of NT-4 are 96% homologous. NT-4 has been shown topromote dendritic outgrowth and calcium currents in cultured mesencephalic dopamine neurons,6to promote growth and remodeling of adult motor neuron innervation,7 to be anterogradesurvival factors for postsynaptic cells8 and to protect against apoptotic neuronal death.9 The biological effects of NT-4 are mediated by two receptors: TrkB, which is specific forNT-4 and BDNF, and p75 which binds all the neurotrophins.10
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
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Synonyms |
Neurotrophin-4, NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4, NTF4, NTF5
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Images |
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Specification |
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Quantity |
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| 3 | Leading Biology | APR12422G | Human H4 Histamine Receptor (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
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| 4 | Leading Biology | APR03844G | UBE2W Antibody (C-term) | 100 μl | Polyclonal Antibodies |
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| 5 | Leading Biology | APR04349G | HECTD2 Antibody (N-term) | 100 μl | Polyclonal Antibodies |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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$495.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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