> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CNTF AntibodyBrand |
Leading Biology | Catalog Number |
APR11614G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CNTF antibody.
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Molecular Weight |
22931 Da
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Host |
Rabbit
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Species Reactivity |
Human, Rat
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Target |
Peptide (C)ELSQWTVRSIHDLR, corresponding to amino acid residues 164-177 of human CNTF (Accession P26441). C-terminus.
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GeneID |
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UniProt ID |
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Summary |
CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily1.It was initially purified from the chick eye on the basis of its ability topromote survival of E8 chick ciliary ganglion neurons in culture2.CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstratedthat CNTF is ubiquitously distributed in neurons and glia throughoutthe rodent brain4. CNTF effects are mediated by a tripartite receptor complex consisting of two signal-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFR)5.CNTF can support the survival of many different cell populations within the PNS and the CNS6. in vitro, CNTF promotes proliferation and neuronal specificationsin hippocampal neurons. in vivo, it supports the viability of non-primate motor neurons7, CNTF induces sprouting of cholinergicmotor neurons8 and delays neural degeneration in genetic modelsof motor neuron disease9. In addition, it is involved in the development stage of astrocytes and oligodendocytes10.Abgent is pleased to offer a highly specific antibody directed against an epitope of human CNTF. Anti-CNTF (#AG1166) antibody can be used in western blotand immunocytochemical applications,and has been designed to recognize CNTF from human, rat and mouse samples. In addition, Anti-CNTF specifically recognizes CNTF but not related cytokines.
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
IHC~~1:200
ICC~~1:200
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Synonyms |
Ciliary neurotrophic factor, CNTF, CNTF
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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