> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > K2P5.1 (TASK-2) AntibodyBrand |
Leading Biology | Catalog Number |
APR08067G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality K2P5.1 (TASK-2) antibody.
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Molecular Weight |
55130 Da
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Host |
Rabbit
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Species Reactivity |
Rat
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Target |
Peptide (C)YEQLMNEYNKANSPKGT, amino acid residues 483-499 of human K2P5.1 (Accession number O95279).????Intracellular, C-terminus.
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GeneID |
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UniProt ID |
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Summary |
K2P5.1 (also named TWIK-Related Acid Sensitive K+ channel 2, TASK-2 or KCNK5) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be “leak” or “background” K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. The functional channel is believed to be a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators.As indicated by its name, K2P5.1 is sensitive to variations in external pH. K2P5.1 current is maximal at pH 8.8 but it is only 10% at pH 6.5.The channel is expressed in several epithelial tissues including pancreas, lung, small intestine and specially kidney. In the kidney K2P5.1 has an important function in NaHCO3 absorption in the proximal tubule as knockout mice for K2P5.1 display metabolic acidosis and hypotension.
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
IHC~~1:50
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Synonyms |
Potassium channel subfamily K member 5, Acid-sensitive potassium channel protein TASK-2, TWIK-related acid-sensitive K(+) channel 2, KCNK5, TASK2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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