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KV11.2 (erg2) Antibody

Catalog # Availability Size / Price Inquiry
AMM06220G 50 μl / $695

KV11.2 (erg2) Antibody

Brand

Leading Biology

Catalog Number

AMM06220G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KV11.2 (erg2) antibody.

Molecular Weight

109925 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Peptide TLNFVEFNLEKHRS(C), corresponding to amino acid residues 185-198 of human Kv11.2 (Accession??Q9H252).????Intracellular, N-terminal part.

GeneID

UniProt ID

Summary

Kv11.2 (erg2) is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels. The erg subfamily includes the closely related proteins Kv11.1 (erg1) and Kv11.3 (erg3) that possess the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels, the functional channel is a tetramer composed of four subunits. It has been suggested that the Kv11 subfamily members can form functional heteromultimers within the subfamily.Kv11.2 produces currents characterized by strong inward rectification with slow activation and very rapid inactivation kinetics, which closely resemble those produced by the much studied channel Kv11.1.The expression of Kv11.2 seems to be limited to the brain and the pituitary gland. The same is true for the Kv11.3 protein, while Kv11.1 is more widely expressed.From a pharmacological point of view, Kv11.2 channels can be blocked by well characterized organic blockers such as the anti-arrhythmic drug E-4031 (#E-500). In addition, the peptide toxins Ergtoxin-1 (#RTE-450) and BeKm-1 (#RTB-470), block Kv11.2 with different potencies.Alomone has now produced a new Anti-Kv11.2 antibody directed against a highly conserved epitope of the human protein. The antibody was used to detect Kv11.2 in rat samples using both Western blotting and immunohistochemistry.

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~1:200-1:2000

Synonyms

Potassium voltage-gated channel subfamily H member 6, Ether-a-go-go-related gene potassium channel 2, ERG-2, Eag-related protein 2, Ether-a-go-go-related protein 2, hERG-2, hERG2, Voltage-gated potassium channel subunit Kv112, KCNH6, ERG2

Images

Western blot analysis of rat brain (1 and 3) and rat cortex ( 2 and 4) lysate: 1, 2. Anti-K 11.2 (erg2) antibody ( AMM06220G), (1:200). 3, 4. Anti-K 11.2 (erg2) antibody, preincubated with the control peptide antigen.

Expression of K 11.2 in rat hippocampus Immunohistochemical staining of K 11.2 in rat hippocampus using Anti-K 11.2 (erg2) antibody ( AMM06220G). A. K 11.2 appears as diffuse staining (green) that defines the boundary of the reticular nucleus of thalamus (arrow). B. Staining with mouse anti-parvalbumin (PV, red) demonstrates both neuronal and diffuse staining. C. Confocal merge of K 11.2 and PV demonstrates overlap of the two markers labeling the reticular nucleus of the thalamus (orange).

Specification

Quantity

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