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P2Y4 Receptor Antibody

Catalog # Availability Size / Price Inquiry
APR17721G 50 μl / $695

P2Y4 Receptor Antibody

Brand

Leading Biology

Catalog Number

APR17721G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality P2Y4 Receptor antibody.

Molecular Weight

40894 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Peptide (C)HEES ISRWA DTHQD, corresponding to residues 337-350 of rat P2Y4 (Accession O35811). Intracellular, C-terminus.

GeneID

UniProt ID

Summary

The P2Y receptors belong to the G-protein coupled receptors superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiologic responses, among them, cardiac function,platelet aggregation and SMC proliferation.1The mammalian P2Y family currently includes eight functional receptors; P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y14.2-4The P2Y4-receptor is highly expressed in the placenta and with lower levels at lung and vascular smooth muscle.5The human P2Y4 receptor is highly selective to UTP while rat P2Y4 receptor is equally activated by both UTP and ATP and also by other triphosphate nucleotides such as Ap4A.5Recently it has been shown that P2Y4 receptor is involved in differentiation and cell death of human neuroblastoma SH-SY5Y cells.6Abgent is pleased to offer a highly specific antibody directed against the C terminus domain of the rat P2Y4 receptor.Anti-P2Y4 Receptorantibody (#AG1072) can be used in western blot analysis, immunoprecipitation, indirect flow cytometry, immunocytochemistryand immunohistochemistry, and recognizes P2Y4 in rat samples.

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IP

Dilution

WB~~1:200-1:2000

Synonyms

P2Y purinoceptor 4, P2Y4, P2ry4, P2y4

Images

Western blot analysis of rat brain membranes: 1. Anti-P2Y4 Receptor antibody ( APR17721G), (1:300). 2. Anti-P2Y4 Receptor antibody, preincubated with the control peptide antigen.

Expression of P2Y4 receptor in rat cerebellum Immunohistochemical staining of rat cerebellum using Anti-P2Y4 Receptor antibody ( APR17721G). A. P2Y4 receptor (red) appears in astrocytic processes (arrows). B. In contrast, P2Y4 receptor does not appear in Purkinje neuronal dendrites stained for calbindin D28k (green) in the same brain section. This demonstrates the restriction of P2Y4 receptor to astrocytic fibers.

Specification

Quantity

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