> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > AKAP4 AntibodyBrand |
Leading Biology | Catalog Number |
APR14895G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AKAP4 antibody.
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Molecular Weight |
Predicted: 94 kDa Observed: 100 kDa
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Cellular Localization |
Antigen Cellular Localization:
Cell projection, cilium, flagellum. Note=Localizes to the principle piece of the sperm flagellum
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
AKAP4; AKAP4 antibody is human specific. At least three isoforms are known to exist; this antibody will detect the two longest isoforms.
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Isotype |
IgG
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Symbol |
AKAP82
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GeneID |
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UniProt ID |
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Function |
Major structural component of sperm fibrous sheath. Plays a role in sperm motility.
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Summary |
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell (1). AKAP4, also known as hAKAP82, is a major sperm fibrous sheath protein that localizes to the entire length of the flagellum of human sperm (2). It has been suggested that AKAP4 plays multiple roles in sperm motility and regulation of signal transduction pathways (2). AKAP4 has also been postulated to be a potential biomarker for breast cancer (3).
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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