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CRH Antibody

Catalog # Availability Size / Price Inquiry
APR11666G 0.1 mg / $695

CRH Antibody

Brand

Leading Biology

Catalog Number

APR11666G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CRH antibody.

Molecular Weight

Predicted: 22 kDa Observed: 29 kDa

Cellular Localization

Antigen Cellular Localization: Secreted.

Host

Rabbit

Species Reactivity

Human

Target

CRH; CRH antibody is human specific.

Isotype

IgG

GeneID

UniProt ID

Function

This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

Summary

Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1). In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2). Marked reduction in this protein has been observed in association with Alzheimer disease (3).

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of CRH in human placenta tissue lysate with CRH antibody at (A) 1 and (B) 2 μg/ml.

Immunohistochemistry of CRH in human brain tissue with CRH antibody at 5 μg/mL.

Immunofluorescence of CRH in human brain tissue with CRH antibody at 20 μg/mL.

Specification

Quantity

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