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CISD2 Antibody

Catalog # Availability Size / Price Inquiry
APR15451G 0.1 mg / $695

CISD2 Antibody

Brand

Leading Biology

Catalog Number

APR15451G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CISD2 antibody.

Molecular Weight

Predicted: 15 kDa Observed: 15 kDa

Cellular Localization

Antigen Cellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

CISD2;

Isotype

IgG

Symbol

CDGSH2, ERIS, ZCD2

GeneID

UniProt ID

Function

Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.

Summary

CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of CISD2 in rat brain tissue lysate with CISD2 antibody at (A) 1 and (B) 2 μg/m

Immunohistochemistry of CISD2 in rat brain tissue with CISD2 antibody at 2.5 μg/ml.

Immunofluorescence of CISD2 in rat brain tissue with CISD2 antibody at 20 μg/ml.

Specification

Quantity

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