> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TCIRG1 AntibodyBrand |
Leading Biology | Catalog Number |
APR10389G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TCIRG1 antibody.
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Molecular Weight |
91 kDa
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
TCIRG1; At least two alternatively spliced isoforms are known to exist; this antibody will only detect the larger isoform.
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Isotype |
IgG
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Symbol |
ATP6N1C, ATP6V0A3
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GeneID |
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UniProt ID |
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Function |
Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
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Summary |
TCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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