• Account
  • Account
    Inquiries
    0

    Inquired items

    0 items total Subtotal:$ 0
  • 会员中心
    Cart

    Added items

    0items total Subtotal:$ 0

All Departments

SCARB1 Antibody

Catalog # Availability Size / Price Inquiry
AMR09818G 0.1 mg / $695

SCARB1 Antibody

Brand

Leading Biology

Catalog Number

AMR09818G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SCARB1 antibody.

Molecular Weight

Predicted: 56, 60 kDa Observed: 60 kDa

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

SCARB1; At least two isoforms of SCARB1 are known to exist; this antibody can detect both isoforms.

Isotype

IgG

Symbol

CD36L1, CLA1

GeneID

UniProt ID

Function

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

Summary

SCARB1 Antibody: Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of SCARB1 in human spleen tissue lysate with SCARB1 antibody at (A) 1 and (B) 2 μg/mL.

Immunohistochemistry of SCARB1 in human spleen tissue with SCARB1 antibody at 2.5 μg/mL.

Immunofluorescence of SCARB1 in Human Spleen tissue with SCARB1 antibody at 20 μg/mL.

Specification

Quantity

Related Products

Select Brand Catalog No. Product Name Pack Size Type Field of Research Specification Quantity Price(USD)
1 Leading Biology APR03440G ITGA11 Antibody (N-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
2 Leading Biology APR04537G CMIP Antibody (C-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
3 Leading Biology APR13816G TRPM5 Antibody 50 μl Polyclonal Antibodies
$695.00 Add Ask
4 Leading Biology APR04506G PCOLCE2 Antibody (Center) 100 μl Polyclonal Antibodies
$495.00 Add Ask
5 Leading Biology APR26894N ASPH Polyclonal Antibody 100ul Polyclonal Antibodies Neuroscience>Calcium Signaling
$495.00 Add Ask
6 Leading Biology APR05221G Phospho-SMAD2(S118) Antibody 100 μl Polyclonal Antibodies
$495.00 Add Ask
Contact Us

This item has successfully been added to your cart!

You have 0 item in your cart

Your inquiry has successfully been added to your list!

You have 0 item in your inquiry list