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Nhe-1 Antibody

Catalog # Availability Size / Price Inquiry
APR08736G 0.1 mg / $695

Nhe-1 Antibody

Brand

Leading Biology

Catalog Number

APR08736G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Nhe-1 antibody.

Molecular Weight

Predicted: 52, 90 kDa Observed: 50, 90 kDa

Cellular Localization

Antigen Cellular Localization: Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

SLC9A1; At least three isoforms of Nhe-1 are known to exist.

Isotype

IgG

Symbol

APNH1, NHE1

GeneID

UniProt ID

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Summary

Nhe-1 Antibody: The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of Nhe-1 in rat kidney tissue lysate with in with Nhe-1 antibody at (A) 1 and (B) 2 μg/mL.

Immunohistochemical staining of human brain tissue using Nhe-1 antibody at 2.5 μg/mL.

Immunofluorescence of Nhe-1 in Human Brain tissue with Nhe-1 antibody at 20 μg/mL.

Specification

Quantity

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