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DRAM Antibody

APR07624G Product Datasheet Protocol

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APR07624G		0.1 mg / $695

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Leading Biology Inc.

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DRAM Antibody

Brand	Leading Biology	Catalog Number	APR07624G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DRAM antibody.
Molecular Weight	26253 Da
Cellular Localization	Antigen Cellular Localization: Lysosome membrane; Multi-pass membrane protein
Host	Rabbit
Species Reactivity	Human, Mouse, Rat
Target	DRAM;
Isotype	IgG
Symbol	DRAM
GeneID	55332
UniProt ID	Q8N682
Function	Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy.
Summary	DRAM Antibody: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
Form	Liquid
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, IF, E
Synonyms	DRAM Antibody: DRAM, DRAM, DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, damage-regulated autophagy modulator
Images	Western blot analysis of DRAM in 293 cell lysate with DRAM antibody at (A) 0.5 and (B) 1 μg/mL. Immunohistochemistry of DRAM in human liver tissue with DRAM antibody at 2.5 μg/mL. Immunofluorescence of DRAM in Human Liver cells with DRAM antibody at 20 μg/mL.
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