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TRPC3 Antibody

Catalog # Availability Size / Price Inquiry
APR13804G 0.1 mg / $695

TRPC3 Antibody

Brand

Leading Biology

Catalog Number

APR13804G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRPC3 antibody.

Molecular Weight

96009 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Multi-pass membrane protein.

Host

Rabbit

Species Reactivity

Human, Mouse

Target

TRPC3;

Isotype

IgG

Symbol

TRP3

GeneID

UniProt ID

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.

Summary

TRPC3 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Synonyms

TRPC3 Antibody: TRP3, TRP3, Short transient receptor potential channel 3, Transient receptor protein 3, TrpC3, transient receptor potential cation channel, subfamily C, member 3

Images

Western blot analysis of TRPC3 in human brain tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 μg/mL.

Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody at 2 μg/mL.

Immunofluorescence of TRPC3 in Mouse Heart cells with TRPC3 antibody at 20 μg/mL.

Specification

Quantity

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