> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Plexin-A1 (extracellular) AntibodyBrand |
Leading Biology | Catalog Number |
APR12897G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Plexin-A1 (extracellular) antibody.
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Molecular Weight |
211067 Da
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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GeneID |
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UniProt ID |
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Summary |
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).
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Form |
Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Synonyms |
Plexin-A1, Semaphorin receptor NOV, PLXNA1, NOV, PLXN1
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Images |
Western blot analysis of rat (lanes 1 and 3) and mouse brain synaptosomal fraction (lanes 2 and 4):1, 2. Anti-Plexin-A1 (extracellular) antibody ( APR12897G), (1:400).3, 4. Anti-Plexin-A1 (extracellular) antibody, preincubated with the control peptide antigen.
Immuno-colocalization of GluN1 and Plexin-A1 in rat olfactory bulb Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using guinea pig Anti-NMDA Receptor 1 (GluN1) (extracellular) antibody ( AGP-046), (1:600) and rabbit Anti-Plexin-A1 (extracellular) antibody ( APR12897G), (1:400). A. GluN1 (green) is expressed in the glomeruli (horizontal arrows). B. Plexin A1 staining (red) in the same section, shows expression in the glomeruli (arrow) but also in other layers (vertical arrow) of the olfactory bulb. C. Merge of the two images show cases co-localization in the glomeruli vs. lack of co-localization in deeper layers of the olfactory bulb. Cell nuclei are stained with DAPI (blue). |
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Specification |
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Quantity |
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Tel: 1-661-524(LBI)-0262
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