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Human TRPM1 Antibody

Catalog # Availability Size / Price Inquiry
APR16789G 50 μl / $695

Human TRPM1 Antibody

Brand

Leading Biology

Catalog Number

APR16789G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Human TRPM1 antibody.

Host

Rabbit

Species Reactivity

Human

Target

Peptide (C)EEKKVKKEKASTETE, corresponding to amino acid residues 1518-1533 of human TRPM1 (Accession O75560).??Intracellular, C-terminus.Will not recognize rat or mouse TRPM1.

GeneID

UniProt ID

Summary

The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named after the first discovered member melastatin (TRPM1) whose gene was identified in metastatic and benign melanomas.The TRPM family consist of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM7.The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N-terminus and C-terminus. However, due to their long N-terminus and C-terminus they were also named the long TRP channel family.TRPM channels were suggested to play a role in tumourigenesis, proliferation and differentiation.Recently, TRPM1 was found to be down-regulated in a highly metastatic line. The loss of TRPM1 expression has been reported to be correlated to melanoma aggressiveness.Two alternative splice variants of TRPM1 were reported; short (TRPM1-S) and long (TRPM1-L). The TRPM1-S was described to be expressed at human melanocyte and mainly in metastasic melanoma cell lines. While TRPM1-L is expressed at murine CNS.Abgent is pleased to introduce a new antibody directed to the humanTRPM1, Anti-Human TRPM1 antibody, to our growing line of TRP antibodies

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~1:200-1:2000

Synonyms

TRPM1

Images

Western blot analysis of A875 (human melanoma cell line) lysate: 1. Anti-Human TRPM1 antibody ( APR16789G), (1:200). 2. Anti-Human TRPM1 antibody, preincubated with the control peptide antigen.

Specification

Quantity

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