We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Cannabinoid Receptor 2 antibody.

39359 Da

Rabbit

Rat

Peptide (C)DRQVPGIARMRLDVR, corresponding to amino acid??residues 228-242 of rat CB2R (Accession Q9QZN9). 3rd?? Intracellular loop.

Cannabinoids have been used as pain relievers in eastern medicine for many years.1 To date, two specific cannabinoid receptors have been identified: the Cannabinoid Receptor 1 (CB1R) and the Cannabinoid Receptor 2 (CB2R).2 The cannabinoid receptors can be distinguished by their amino acid sequence, signaling mechanisms and tissue distribution.2 Both receptors belong to the G-protein coupled receptor superfamily and are coupled to Gi/0 G protein.2,3The CB2R is highly expressed in cells of the immune system such as macrophages, lymphocytes natural killer cells and mast cells but has also been shown to be expressed, by both, in situ-hybridization and in immunohistochemistry, in spleen, thymus, and pancreas.1,2,4 CB2R expression in brain is still much less characterized than that of CB1R. Recently, it was demonstrated that CB2R is expressed in brain and might have role in controlling fundamental processes such as proliferation and survival of neural cells.5,6Overexpression of CB2R was reported in several cancers such as prostate, glioma and acute myeloid leukemias.7-9 In human astrocytoma a direct relationship between CB2R expression and tumor malignancy was demonstrated.8 Activation of CB2R, in vivo, by its agonist JWH-133, completely blocked cell growth.8 In C6 glioma it was shown that activation of the CB2R by JWH-133 resulted in the internalization of only the CB2R, and not CB1R leading to apoptosis of the cells. This may well bea new approach for the treatment of glioma.Alomone is pleased to offer a new antibody directed against an intracellular epitope of therat CB2 receptor. Anti-Cannabinoid Receptor2antibody (#AG1436) can be used in western blot andimmunohistochemistry applications, and recognizes CB2R inrat samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB

WB~~1:200-1:2000 IHC~~1:100

Cannabinoid receptor 2, CB-2, CB2, rCB2, Cnr2

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