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TRPV6 Antibody

Catalog # Availability Size / Price Inquiry
APR10545G 50 μl / $695

TRPV6 Antibody

Brand

Leading Biology

Catalog Number

APR10545G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRPV6 antibody.

Molecular Weight

83210 Da

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Peptide (C)NRGLEDGESWEYQI, corresponding to amino acid residues 712-725 of human TRPV6 (Accession Q9H1D0).????Intracellular, C-terminus.

GeneID

UniProt ID

Summary

TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5TRPV6 (CaT1) and TRPV5 (ECaC) are unique members of the TRP family. Both are epithelial calcium channels, form constitutively open channels, share high degree of homology (about 66%) with differences in the N and C-terminus. TRPV6 and TRPV5 are expressed in a 1,25-dihydroxyvitamin D3 dependent manner. In contrast to other members of the TRP family, TRPV6 and TRPV5 are highly Ca2+ selective and are expressed in Ca2+ transporting epithelia where they are assumed to have an important role in Ca2+ reabsorption. TRPV6 is highly expressed in the placenta, small intestine and kidney.6,7While not being expressed in benign prostate tissue, TRPV6 was found to be upregulated in prostate cancer tissue and correlation between expression and tumor grade was shown. Finally, TRPV6 was suggested as prognostic marker and as a promising candidate for therapeutic strategies.8,9Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of the human TRPV6. Anti-TRPV6 antibody (#AG1347) can be used in western blot analysis, immunoprecipitation, immunocytochemicaland immunohistochemical applications. It has been designed to recognize TRPV6 from human, rat and mouse samples.

Form

Affinity purified antibody, Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IP

Dilution

WB~~1:200-1:2000 IHC~~1:100 ICC~~1:100

Synonyms

Transient receptor potential cation channel subfamily V member 6, TrpV6, CaT-like, CaT-L, Calcium transport protein 1, CaT1, Epithelial calcium channel 2, ECaC2, TRPV6, ECAC2

Images

Western blot analysis of PC-3 cell lysate: 1. Anti-TRPV6 antibody ( APR10545G), (1:200). 2. Anti-TRPV6 antibody, preincubated with the control peptide antigen.

Expression of TRPV6 in rat DRG Immunohistochemical staining of rat dorsal root ganglion (DRG) using Anti-TRPV6 antibody ( APR10545G), (1:100). A. TRPV<span dir="rtl">6 channel (red) in DRG neurons. B. Staining with mouse anti-Parvalbumin (green) in the same DRG section. C. Confocal merge of TRPV<span dir="rtl">6 and Parvalbumin demonstrates colocalization (arrows).

Expression of TRPV6 in PC-3 cells Immunocytochemical staining of paraformaldehyde-fixed PC-3 cells with Anti-TRPV6 antibody ( APR10545G), (1:100) followed by goat anti-rabbit-AlexaFluor-555 secondary antibody (A) or with a mixture of Anti-TRPV6 and TRPV6 peptide antigen (1:20) (B). Hoechst 33342 is used as the counterstain (blue).

Specification

Quantity

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