We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRPM8 (extracellular) antibody.

127685 Da

Rabbit

Human, Mouse, Rat

Peptide SDVDGTTYDFAHC,??corresponding to amino acid residues 917-929 of human TRPM8 (Accession Q7Z2W7).????3rd extracellular loop.

The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The family was named afterthe first member, melastatin (TRPM1), whose gene was identified in metastatic and benign melanomas.1 The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N-terminus and C-terminus. However, due to theirlong N-terminus and C-terminus they were also named the long TRP channel family.1The TRPM family consists of eight members designated as TRPM1-8 that can be further divided into four pairs: TRPM1 and TRPM3; TRPM2 and TRPM8; TRPM4 and TRPM5; and TRPM6 and TRPM7.1The TRPM8 channel is the cold and menthol receptor activated by either cold temperatures(~28°C) or menthol.2TRPM8 is expressed in dorsal root ganglia (DRGs) where about 5%-10% of the small diameter DRG neurons express the channel.3,4 In DRGs, TRPM8 expressing neurons do not express the TRPV1 channel.5 Overexpression of TRPM8 was found in prostate cancer cells. However, the physiological and pathological roles that these cells play is still elusive.6 In prostate, it was suggested that TRPM8 mightplay a possible role in the progression of cancer to the metastatic stage.6Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of human TRPM8. Anti-TRPM8 (extracellular) antibody (#AG1341) can be used in western blot analysis, immunoprecipitation, immunohistochemical and immunocytochemical applications. It recognizes TRPM8 from human, rat and mouse samples.

Affinity purified antibody, Liquid

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

WB, IP

WB~~1:200-1:2000 IHC~~1:100 ICC~~1:500

Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, TRPM8, LTRPC6, TRPP8

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