> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > M2 Muscarinic Receptor AntibodyBrand |
Leading Biology | Catalog Number |
APR12489G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality M2 Muscarinic Receptor antibody.
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Molecular Weight |
51715 Da
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
GST fusion protein with a sequence VANQDPVSPSLVQGRIVKPN NNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV SAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS DSCTPTNTTVEVVGSSGQNGDE, corresponding to amino acid?residues 225-356 of human m2 (Accession P08172). 3rd intracellular loop.
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GeneID |
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UniProt ID |
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Summary |
The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein-coupled receptors. Five subtypes of muscarinic receptors have been cloned and are named m1-m5.1-2The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exerts both excitatory and inhibitory control over central and peripheral tissues.1-2Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control.1 They also participate in learning and memory processing.3-4The m2 receptor is considered to be the predominant muscarinic receptor that is expressed in cardiac muscle.5The m2 and m4 receptors mediate Ca2+ channel inhibition and Kir3 K+ channel activation by directly binding the Gbg subunit to the channel.6,7 Stimulation of the m2 receptor by acetylcholine in the heart results in activation of the Kir3.1/Kir3.4 channels causing a slowing in heart beat.7 Abgent is pleased to offer a highly specific antibody directed against the 3rd intracellular loop of the human m2 receptor. Anti-M2 Muscarinic Receptor antibody (#AG1218) can be used in western blot analysis, immunoprecipitation, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize m1 from mouse and rat and human samples.
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Form |
Affinity purified antibody, Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, IP, ICC
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Dilution |
WB~~1:200-1:2000
IHC~~1:100
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Synonyms |
Muscarinic acetylcholine receptor M2, CHRM2
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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