> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > EDEM3 AntibodyBrand |
Leading Biology | Catalog Number |
AMM07005G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EDEM3 antibody.
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Molecular Weight |
104664 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
EDEM3
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Isotype |
Rabbit IgG
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Symbol |
C1orf22
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GeneID |
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UniProt ID |
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Function |
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).
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Summary |
EDEM3 belongs to the glycosyl hydrolase 47 family. It is involved in endoplasmic reticulum-associated degradation (ERAD). Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 accelerates the degradation of misfolded glycoproteins in the ER. It also accelerates the glycoprotein ERAD by proteasomes and this process depends on mannose-trimming from the N-glycans. It is most likely to have some alpha 1, 2-mannosidase activity.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
Alpha-1, 2-mannosidase EDEM3
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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