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DSG3 Antibody

Catalog # Availability Size / Price Inquiry
AMM06959G 100 μl / $545

DSG3 Antibody

Brand

Leading Biology

Catalog Number

AMM06959G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DSG3 antibody.

Molecular Weight

107.5kDa

Cellular Localization

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome

Host

Mouse

Species Reactivity

Human

Clone

6G2C11

Isotype

IgG1

Symbol

CDHF6

GeneID

UniProt ID

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Summary

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. ; ;

Form

Liquid. In PBS containing 0.02% sodium azide.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC, FC, E

Dilution

E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000

Synonyms

Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, Cadherin family member 6, DSG3, CDHF6

Images

Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Figure 1: Western blot analysis using DSG3 mAb against human DSG3 (AA: 55-159) recombinant protein. (Expected MW is 37.5 kDa)

Figure 2: Western blot analysis using DSG3 mAb against HEK293 (1) and DSG3 (AA: 55-159)-hIgGFc transfected HEK293 (2) cell lysate.

Specification

Quantity

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