> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Bcl-xL AntibodyBrand |
Leading Biology | Catalog Number |
APG02229G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Bcl-xL antibody.
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Molecular Weight |
18392 Da
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Cellular Localization |
Antigen Cellular Localization:
Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
Bcl-xl
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Isotype |
Rabbit IgG
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Symbol |
BBC6, BCL2L8
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GeneID |
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UniProt ID |
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Function |
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
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Summary |
Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis thro μgh two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IP
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Synonyms |
Bcl-xL, Bcl-xS, BCL2L1, BCL2-like 1 protein
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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