> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > UBN1 / Ubinuclein 1 Antibody (aa161-210)Brand |
Leading Biology | Catalog Number |
APR11239G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UBN1 / Ubinuclein 1 antibody (aa161-210).
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Molecular Weight |
121520 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Target |
Ubinuclein Antibody detects endogenous levels of total Ubinuclein protein.
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Function |
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.
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Summary |
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly.
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Form |
Liquid. In PBS containing 0.02% sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
IHC-P, IF, E
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Dilution |
ELISA (1:10000), IF (1:100 - 1:500), IHC-P (10 μg/ml),
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Synonyms |
UBN1, HIRA-binding protein, Protein VT4, VT, Ubinuclein-1, VT4, Ubinuclein 1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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