• Account
  • Account
    Inquiries
    0

    Inquired items

    0 items total Subtotal:$ 0
  • 会员中心
    Cart

    Added items

    0items total Subtotal:$ 0

All Departments

Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > FNBP1 / FBP17 Antibody (aa30-80)

FNBP1 / FBP17 Antibody (aa30-80)

Catalog # Availability Size / Price Inquiry
APR16014G 50 μg / $495

FNBP1 / FBP17 Antibody (aa30-80)

Brand

Leading Biology

Catalog Number

APR16014G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FNBP1 / FBP17 antibody (aa30-80).

Molecular Weight

71kDa

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Human FNBP1

Symbol

FBP17, KIAA0554

GeneID

UniProt ID

Function

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.

Summary

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P

Dilution

IHC-P (10 μg/ml), WB (0.1-0.2 μg/ml),

Synonyms

Formin-binding protein 1, Formin-binding protein 17, hFBP17, FNBP1, FBP17, KIAA0554

Images

Western blot of FNBP1 in human liver lysate in the 1) absence and 2) presence of immunizing...

Anti-FNBP1 / FBP17 antibody IHC of human brain, cortex neurons.

Specification

Quantity

Related Products

Select Brand Catalog No. Product Name Pack Size Type Field of Research Specification Quantity Price(USD)
1 Leading Biology APR03440G ITGA11 Antibody (N-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
2 Leading Biology APR04537G CMIP Antibody (C-term) 100 μl Polyclonal Antibodies
$495.00 Add Ask
3 Leading Biology APR13816G TRPM5 Antibody 50 μl Polyclonal Antibodies
$695.00 Add Ask
4 Leading Biology APR04506G PCOLCE2 Antibody (Center) 100 μl Polyclonal Antibodies
$495.00 Add Ask
5 Leading Biology APR26894N ASPH Polyclonal Antibody 100ul Polyclonal Antibodies Neuroscience>Calcium Signaling
$495.00 Add Ask
6 Leading Biology APR05221G Phospho-SMAD2(S118) Antibody 100 μl Polyclonal Antibodies
$495.00 Add Ask
Contact Us

This item has successfully been added to your cart!

You have 0 item in your cart

Your inquiry has successfully been added to your list!

You have 0 item in your inquiry list