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Primary Antibody >
Polyclonal Antibodies >
KRT17 / CK17 / Cytokeratin 17 Antibody (aa381-430)Brand |
Leading Biology | Catalog Number |
APR17061G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KRT17 / CK17 / Cytokeratin 17 antibody (aa381-430).
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Molecular Weight |
48kDa
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
Keratin 17 Antibody detects endogenous levels of total Keratin 17 protein.
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GeneID |
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UniProt ID |
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Function |
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
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Summary |
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
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Form |
Liquid. In PBS containing 0.02% sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, E
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Dilution |
ELISA (1:20000), IF (1:100-1:500), IHC-P (10 μg/ml), WB (1:500-1:1000) ,
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Synonyms |
Keratin, type I cytoskeletal 17, 39.1, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17
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Images |
Immunofluorescence of HepG2 cells, using Keratin 17 Antibody. Western blot of extracts from HUVEC cells, using Keratin 17 Antibody. Anti-KRT17 / Cytokeratin 17 antibody IHC of human tonsil. |
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Specification |
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Quantity |
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