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DOK1 Antibody (C-Terminus)

Catalog # Availability Size / Price Inquiry
APR07615G 50 μg / $495

DOK1 Antibody (C-Terminus)

Brand

Leading Biology

Catalog Number

APR07615G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DOK1 antibody (C-Terminus).

Molecular Weight

52kDa

Cellular Localization

Antigen Cellular Localization: Isoform 1: Cytoplasm. Nucleus.

Host

Rabbit

Species Reactivity

Human

Target

peptide corresponding to amino acids near the carboxy terminus of human p62dok

GeneID

UniProt ID

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Summary

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, ICC

Dilution

IHC-P (5 μg/ml), WB (0.5-1 μg/ml),

Synonyms

Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1

Images

Immunocytochemistry of DOK1 in K562 cells with DOK1 antibody at 2 ug/ml.

Immunofluorescence of DOK1 in K562 cells with DOK1 antibody at 10 ug/ml.

Western blot of DOK1 in Jurkat (Jur) and THP-1 (THP) cell lysates with DOK1 antibody at 1 ug/ml.

Specification

Quantity

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