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Cleaved-Caspase-1 Antibody

Catalog # Availability Size / Price Inquiry
APG02632G 50 μl / $495

Cleaved-Caspase-1 Antibody

Brand

Leading Biology

Catalog Number

APG02632G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Cleaved-Caspase-1 antibody.

Molecular Weight

45159 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Target

Cleaved Caspase-1

Isotype

Rabbit IgG

Symbol

IL1BC, IL1BCE

GeneID

UniProt ID

Function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Summary

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Cleaved-caspase-1 (D210) detects levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.

Form

50 μl purified antibody supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC, E

Synonyms

CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, IL1BC, IL1BCE, CASP1

Images

Western blot analysis of anti-cleaved-caspase-1 with 3T3 cell lysate. Native form (hollow arrow) and cleaved form (filled arrow) of caspase-1 was deteced using the purified antibody.

Specification

Quantity

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