> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > VDAC/Porin AntibodyBrand |
Leading Biology | Catalog Number |
APR10684G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality VDAC/Porin antibody.
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Molecular Weight |
30773 Da
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Cellular Localization |
Antigen Cellular Localization:
Mitochondrion outer membrane. Cell membrane
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat, Rabbit, Bovine
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Target |
VDAC/Porin
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Isotype |
Rabbit IgG
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Symbol |
VDAC
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GeneID |
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UniProt ID |
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Function |
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
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Summary |
The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin)I is an outer membrane mitochondrial protein. The VDAC protein is tho μght to form the major pores thro μgh which adenine nucleotides are transferred thro μgh the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, ANT, and CypD is tho μght to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Synonyms |
VDAC1, VDAC-1 , MGC111064 , hVDAC1, Porin
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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