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Alpha II Spectrin Antibody

Catalog # Availability Size / Price Inquiry
APR14900G 100 μl / $495

Alpha II Spectrin Antibody

Brand

Leading Biology

Catalog Number

APR14900G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Alpha II Spectrin antibody.

Molecular Weight

240 KDa

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

Recombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin.

UniProt ID

Summary

The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).

Form

neat serum

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

IF, WB

Dilution

WB~~ 1:5000 IF~~ 1:500

Synonyms

Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit, SPTAN1, NEAS, SPTA2

Images

Western blot of mouse brain lysate showing specific immunolabeling of the ~240k alpha II spectrin protein.

Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and nestin (red).

Specification

Quantity

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