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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Monoclonal Antibodies > Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody

Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody

Catalog # Availability Size / Price Inquiry
APR14673G 7 ml / $495

Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody

Brand

Leading Biology

Catalog Number

APR14673G

Product Type

Monoclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 antibody.

Molecular Weight

130kDa

Cellular Localization

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein

Host

Mouse

Species Reactivity

Human, Mouse, Rat, Rabbit, Dog

Clone

CDH16/1071

Isotype

Mouse / IgG1, kappa

GeneID

UniProt ID

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Summary

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.?Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Form

Liquid. In PBS containing 0.02% sodium azide.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

IHC, IF, FC

Synonyms

Cadherin-16, Kidney-specific cadherin, Ksp-cadherin, CDH16

Images

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with KSP-Cadherin Monoclonal Antibody (CDH16/1071)

Formalin-fixed, paraffin-embedded Rat Kidney stained with KSP-Cadherin Monoclonal Antibody (CDH16/1071)

Specification

Quantity

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