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ITPA Antibody (N-term)

APR08049G Product Datasheet Protocol

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APR08049G		100 μl / $495

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Leading Biology Inc.

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ITPA Antibody (N-term)

Brand	Leading Biology	Catalog Number	APR08049G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ITPA antibody (N-term).
Molecular Weight	21446 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_03148, ECO:0000269\|PubMed:11278832}
Host	Rabbit
Species Reactivity	Human
Immunogen	24-51 aa
Target	This ITPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human ITPA.
Isotype	Rabbit Ig
Symbol	C20orf37
GeneID	3704
UniProt ID	Q9BY32
Function	Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Summary	ITPA hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, FC, IF, E
Dilution	WB~~1:1000 IF~~1:25 IHC-P~~1:50~100 FC~~1:10~50
Synonyms	Inosine triphosphate pyrophosphatase {ECO:0000255\|HAMAP-Rule:MF_03148}, ITPase {ECO:0000255\|HAMAP-Rule:MF_03148}, Inosine triphosphatase {ECO:0000255\|HAMAP-Rule:MF_03148}, 36119 {ECO:0000255\|HAMAP-Rule:MF_03148}, Non-canonical purine NTP pyrophosphatase {ECO:0000255\|HAMAP-Rule:MF_03148}, Non-standard purine NTP pyrophosphatase {ECO:0000255\|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate diphosphatase {ECO:0000255\|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate pyrophosphatase {ECO:0000255\|HAMAP-Rule:MF_03148}, NTPase {ECO:0000255\|HAMAP-Rule:MF_03148}, Putative oncogene protein hlc14-06-p, ITPA {ECO:0000255\|HAMAP-Rule:MF_03148}, C20orf37
Images	Western blot analysis of lysates from A375, Hela, HepG2 cell line, mouse brain and rat liver tissue lysate(from left to right), using ITPA Antibody (N-term)( APR08049G). APR08049G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane. Immunofluorescent analysis of Hela cells, using ITPA Antibody (N-term)(Cat. APR08049G). APR08049G was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Dylight Fluor? 554 (red) conjugated Phalloidin (red). ITPA Antibody (N-term) (Cat. APR08049G) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ITPA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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