> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > DOCK2 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR15796G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DOCK2 antibody (C-term).
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Molecular Weight |
211948 Da
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Cellular Localization |
Antigen Cellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
This DOCK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1812-1846 amino acids from the C-terminal region of human DOCK2.
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Isotype |
Rabbit Ig
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Symbol |
KIAA0209
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GeneID |
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UniProt ID |
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Function |
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
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Summary |
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000-1:2000
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Synonyms |
Dedicator of cytokinesis protein 2, DOCK2, KIAA0209
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Images |
Anti-DOCK2 Antibody (C-term)at 1:2000 dilution + Jurkat whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 212 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Western blot analysis of lysates from Jurkat, Raji cell line (from left to right), using DOCK2 Antibody (C-term)( APR15796G). A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane. |
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Specification |
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Quantity |
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Tel: 1-661-524(LBI)-0262
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